Endocrine Abstracts

Hypocalcaemia is one of the common metabolic abnormalities found in hospitalised patients. The most common cause of hypocalcaemia is Vitamin D deficiency. Others causes include hypoparathyroidism, chronic kidney disease and hypomagnesemia. Multiple factors can co-exist in the same patient. We present here a case of hypocalcaemia caused by multiple factors in the same patient. The patient we present probably had multiple factors contributing to hypocalcaemia. Our hypothesis is ...

Despite extensive genomic profiling a better understanding of the contributory factors that promote aggressive thyroid cancer is urgently needed. The proto-oncogenes PBF and PTTG have been implicated in thyroid cancer but there is a lack of information regarding their co-expression and specific roles in tumour progression. Separate studies have previously indicated that PBF and PTTG may disrupt pathways associated with the tumour suppressor p53 that are central to DNA-damage r...

PBF is a multifunctional proto-oncogene overexpressed in thyroid and other endocrine cancers. Previously we identified a functional interaction between PBF and the tumour suppressor p53 in well-differentiated thyroid cancer (WDTC). Here, we delineate the oncogenic mechanisms of PBF, along with its binding partner PTTG, in head and neck cancer (HNSCC), in which TP53 mutations (mutTP53) are common (>50%). HNSCC tissue revealed significant upregulation of PBF and PTTG mRNA (&...